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KMID : 1146820230250010019
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Asian Journal of Kinesiology
2023 Volume.25 No. 1 p.19 ~ p.26
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Myocilin as a Potential Factor for the Fast Type Change in the Muscle Isoform Composition: A Mini Review
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Choi Yun-Suk
Jee Hyun-Seok
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Abstract
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BACKGROUND: Various factors-based properties of the skeletal muscle are determined by mechanical stress, chemical stimuli, neuromuscular stimuli, different protein isoforms etc. The properties of the muscle are formed in the process of the balance between anabolism and catabolism. Especially, the anabolism on the way of the cell proliferation to its differentiation is accompanied by various controlling signal pathways.
OBJECTIVE: The purpose of this study focused on the mTOR/S6K system, Myosin, and Myocilin among these signaling pathways, especially on previously reported studies on the contribution of Myocilin to the skeletal muscle fiber type transformation.
METHODS: To identify the molecular pathways related to muscle development, the KEGG Mapper was used to present the mTOR-related signaling system that has not been identified so far.
RESULTS: Consequently, it suggests that it affects the myogenic process, through the path of PI3K->AKT->MEF2->MyoC->mTOR->p70S6K->S6.
CONCLUSIONS: It also suggests that Myocilin serves as a potential effector to control skeletal muscle cell type. Furthermore, more detailed study on the potential target-oriented (to the fast or slow fiber type change) role of Myocilin for enhancing the health state by adjusted exercise programs developed by its optimal type, intensity, frequency, and time is awaited.
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KEYWORD
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Fast Type Ⅱ, Mhc(Myosin Heavy Chain), Myoc(Myocilin), Slow TypeⅠ, Skeletal Muscle
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